Which of the following solutions should be used to prep the donor site for split-thickness skin graft?

Chlorhexidine is an antiseptic solution commonly used for surgical preparations, particularly in procedures involving skin grafts. It is effective against a broad spectrum of bacteria, including both gram-positive and gram-negative organisms, and has residual antibacterial activity, which helps reduce the risk of infection at the surgical site. Its ability to penetrate organic matter and adhere to the skin provides a thorough level of disinfection that is essential for donor site preparation in skin graft surgeries.

Using chlorhexidine for prepping the donor site ensures a clean and sterile environment, which is crucial for successful grafting and healing. This preparation helps to minimize contamination, thereby promoting better outcomes and minimizing complications post-operatively.

Other antiseptics, while they may have their own indications, do not provide the same level of efficacy or residual action as chlorhexidine. Iodophors and Merthiolate may not be as favored due to potential skin reactions or decreased effectiveness. Avagard, although a hand antiseptic, is not specifically indicated for prepping large surgical areas like the donor site for skin grafting.